SIB 1508Y maleate

Key Product Details

Product Description

SIB 1508Y maleate is a potent neuronal nicotinic ACh receptor agonist (EC₅₀ values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.

Product Specifications for SIB 1508Y maleate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SIB 1508Y maleate

The following data is based on the product molecular weight 302.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.54 mL	33.08 mL
5 mM	0.66 mL	3.31 mL	6.62 mL
10 mM	0.33 mL	1.65 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schneider Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J.Pharmacol.Exp.Ther. 1999 PMID: 10411585
• Cosford (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors. J.Med.Chem. 1996 PMID: 8765504

Product Documents for SIB 1508Y maleate