SU 4312

Key Product Details

Product Description

SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC₅₀ values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.

Product Specifications for SU 4312

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SU 4312

The following data is based on the product molecular weight 264.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.78 mL	18.92 mL	37.83 mL
5 mM	0.76 mL	3.78 mL	7.57 mL
10 mM	0.38 mL	1.89 mL	3.78 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Sun Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 1998 PMID: 9651163
• Zaman Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 1998 PMID: 9920285
• Kendall Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 1999 PMID: 10037737

Product Documents for SU 4312