TH 5487

Key Product Details

Product Description

TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC₅₀ = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Product Specifications for TH 5487

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 5487

The following data is based on the product molecular weight 541.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.24 mL	18.48 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Visnes Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 2018 PMID: 30442810

Product Documents for TH 5487