THPN

Key Product Details

Product Description

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Product Specifications for THPN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for THPN

The following data is based on the product molecular weight 266.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.77 mL	37.55 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Li Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 2015 PMID: 25822914
• Wang Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 2014 PMID: 24316735

Product Documents for THPN