TPPU
Chemical Name: N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
Purity: ≥98%
Biological Activity
TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice.
Bettaieb et al.
Mol.Pharmacol., 2015;88:281 -
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.
Rose et al.
J.Med.Chem., 2010;53:7067 -
Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress.
Ren et al.
Proc.Natl.Acad.Sci.U.S.A., 2016;113:E1944
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