U 90042

Key Product Details

Product Description

U 90042 is a GABA_A receptor ligand that binds with comparable affinities to three receptor subtypes: α₁β₂γ₂, α₃β₂γ₂ and α₆β₂γ₂ (K_i values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α₆β₂γ₂ receptors. Sedative/hypnotic compound.

Product Specifications for U 90042

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for U 90042

The following data is based on the product molecular weight 352.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	9.45 mL	47.24 mL	94.49 mL
1.5 mM	1.89 mL	9.45 mL	18.90 mL
3 mM	0.94 mL	4.72 mL	9.45 mL
15 mM	0.19 mL	0.94 mL	1.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tang U-90042, a sedative/hypnotic compound that interacts differentially with the GABA_A receptor subtypes. J.Pharmacol.Exp.Ther. 1995 PMID: 7473164

Product Documents for U 90042