YZ9

Key Product Details

Product Description

YZ9 is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC₅₀ = 0.183 μM). Also competitively inhibits F-6-P (K_i = 0.094 μM). Inhibits cell growth (GI₅₀ = 2.7 μM) in a XTT-based in vitro toxicology assay.

Product Specifications for YZ9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YZ9

The following data is based on the product molecular weight 234.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.54 mL	42.70 mL	85.40 mL
2.5 mM	1.71 mL	8.54 mL	17.08 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
25 mM	0.17 mL	0.85 mL	1.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Seo Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 2011 PMID: 21957443

Product Documents for YZ9