FRS2 Proteins and Enzymes

FRS2 (FGF R substrate 2; also known as SNT and FRS2 alpha) is a 70-90 kDa member of the FRS family of lipid-anchored docking proteins. It is an intermediary between FGF R and other RTK receptors and their Ras/MAPK signaling cascades. FRS2 contains a membrane-anchoring myristoylation signal (aa 1-6), a PTB domain (aa 13-115) that interacts with FGF ...