Nicastrin Proteins and Enzymes

Nicastrin (NCT) is a 150 - 160 kDa member of the nicastrin family of proteins. It is a component of the aspartyl protease γ-secretase complex and serves to stabilize and direct γ-secretase components to proper positions in the plasma membrane. The γ-secretase complex mediates the cleavage of intramembrane proteins such as notch-1 ...