Telomerase Activators Small Molecules and Peptides

Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme, telomerase reverse transcriptase (TERT). Telomerase adds small repeat sequences of DNA (TTAGGG) to the end of chromosomes - multiple repeats of this hexanucleotide sequence over a 5kb span are known as a telomere.

During normal cellular replication, telomeres are eroded and thus protect the coding sequences of the DNA. The erosion of telomeric sequences is thought to form the basis of the ...