2S,6S-Hydroxynorketamine hydrochloride

Key Product Details

Product Description

2S,6S-Hydroxynorketamine hydrochloride is a ketamine metabolite. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC₅₀ = 0.18 nM). Exerts antidepressant effects in mice.

2R,6R-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Product Specifications for 2S,6S-Hydroxynorketamine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2S,6S-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.11 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355
• Singh KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells. PLoS One 2016 PMID: 27096720

Product Documents for 2S,6S-Hydroxynorketamine hydrochloride