2R,6R-Hydroxynorketamine hydrochloride

Tocris Bioscience | Catalog # 6094

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
Tocris Bioscience

Key Product Details

Description

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects
View all AMPA Receptor Agonists »

Product Description

2R,6R-Hydroxynorketamine hydrochloride is a ketamine metabolite. It enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices and decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). 2R,6R-Hydroxynorketamine upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. Exerts antidepressant effects in mice. Lacks ketamine-related side effects.

2S,6S-Enantiomer and Racemate also available.

Licensing Information

Sold under license from the NIH, US patent 62/313,309

Product Specifications for 2R,6R-Hydroxynorketamine hydrochloride

Molecular Weight

276.16

Formula

C12H14ClNO2.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

CAS Number

1430202-69-9

PubChem ID

121513910

InChI Key

ZQJVHBJDLMIKJK-MHDYBILJSA-N

SMILES

ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.81 50
DMSO 27.62 100

Preparing Stock Solutions for 2R,6R-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.11 mL 36.21 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for 2R,6R-Hydroxynorketamine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 2R,6R-Hydroxynorketamine hydrochloride

For research use only

Citations for 2R,6R-Hydroxynorketamine hydrochloride

Customer Reviews

There are currently no reviews for this product. Be the first to review 2R,6R-Hydroxynorketamine hydrochloride and earn rewards!

Have you used 2R,6R-Hydroxynorketamine hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card