Alantolactone

Key Product Details

Product Description

Alantolactone is a sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.

Product Specifications for Alantolactone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Alantolactone

The following data is based on the product molecular weight 232.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.30 mL	21.52 mL	43.04 mL
5 mM	0.86 mL	4.30 mL	8.61 mL
10 mM	0.43 mL	2.15 mL	4.30 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shi Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and AVNreceptor type II A in AVNsignaling pathway. J.Biomol.Screen. 2011 PMID: 21378277
• Pal Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa. Toxicol.In Vitro. 2010 PMID: 20600805
• Dupuis & Brisson Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes. Chem.Biol.Interact. 1976 PMID: 1000726

Product Documents for Alantolactone