BMP Family
Bone Morphogenetic Proteins (BMPs) are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily. BMPs were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. In addition, differential screening-selected gene aberrative in neuroblastoma (DAN) domain family of BMP antagonists include Cerberus, DAN, Gremlin, PRDC, and Cerberus 1. DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands.
BMPs (Bone Morphogenetic Proteins)
BMP Receptors
BMP Modulators
- Amnionless
- BAMBI/NMA
- BMP-1/PCP
- Brorin/VWC2
- Caronte
- Cerberus 1
- Chordin
- Chordin-like 1/CHRDL1
- Chordin-like 2/CHRDL2
- COCO
- Crossveinless-2/CV-2
- DAN
- Follistatin
- Follistatin-like 1/FSTL1
- Follistatin-related Gene Protein/FLRG
- Gremlin
- IGSF1
- NELL1
- Noggin
- PRDC/GREM2
- SMURF1
- SOST/Sclerostin
- TMEFF1/Tomoregulin-1
- TMEM119
- TSG
- Tsukushi/TSK
- USAG1
Growth/Differentiation Factors (GDFs)
RGMs
Related Information
- Mini-review: Bone Morphogenetic Proteins (BMPs)
- Cytokines in the Nervous System
- Bone Morphogenetic Protein 6
- Growth/Differentiation Factor 5
- BMPs & Activins Influence FSH Synthesis
- GDF-8
- ADMP: A Ventralizing BMP in the Dorsal Embryo
- TGF-beta Superfamily Signaling in ES cells (Mice are Not Men)
- Mouse Ribs & Fly Veins: CV-2 Regulation of BMP Morphogenetic Fields
- TGF-beta Superfamily
- Skeletal System Development