Arcyriaflavin A

Tocris Bioscience | Catalog # 2457

Potent cdk4 inhibitor; also potently inhibits CaM kinase II; antiviral
Tocris Bioscience
Discontinued Product
2457 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description

Potent cdk4 inhibitor; also potently inhibits CaM kinase II; antiviral
View all Cyclin-dependent Kinase Inhibitors »

Product Description

Arcyriaflavin A is a potent cyclin-dependent kinase 4 (cdk4) inhibitor (IC50 value reported between 60 and 190 nM). Displays activity at other cdks in the sub-micromolar range. Also potently inhibits CaM kinase II (IC50 = 25 nM). Inhibits human cytomegalovirus (HCMV) replication in vitro.

Product Specifications for Arcyriaflavin A

Molecular Weight

325.32

Formula

C20H11N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

CAS Number

118458-54-1

PubChem ID

5327723

InChI Key

KAJXOWFGKYKMMZ-UHFFFAOYSA-N

SMILES

O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.53 100

Preparing Stock Solutions for Arcyriaflavin A

The following data is based on the product molecular weight 325.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.37 mL 30.74 mL
5 mM 0.61 mL 3.07 mL 6.15 mL
10 mM 0.31 mL 1.54 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Arcyriaflavin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Arcyriaflavin A

For research use only

Related Research Areas

Cell Cycle
Intracellular Kinases

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  • Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/24/2019
    Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs as assessed using the 5-bromo-2-deoxyuridine (BrdU) and methylthiazoletetrazolium bromide (MTT) assays, and vascular endothelial growth factor (VEGF) ELISA.
    Arcyriaflavin A 2457

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