Cl-HIBO

Key Product Details

Product Description

Cl-HIBO is a subtype-selective and strongly desensitizing AMPA receptor agonist; selective for GluA1 and GluA2 subunit-containing receptors (EC₅₀ values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluA1-4 receptors respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Cl-HIBO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cl-HIBO

The following data is based on the product molecular weight 206.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	24.20 mL	121.01 mL	242.03 mL
1 mM	4.84 mL	24.20 mL	48.41 mL
2 mM	2.42 mL	12.10 mL	24.20 mL
10 mM	0.48 mL	2.42 mL	4.84 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kristensen Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist. Soc.Neurosci.Abstr.
• Bjerrum Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J.Med.Chem. 2003 PMID: 12747796

Product Documents for Cl-HIBO