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Cl-HIBO

Catalog #: 1673 Datasheet / COA / SDS

Discontinued Product

1673 has been discontinued.
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Cl-HIBO | CAS No. 909400-43-7 | AMPA Receptor Agonists
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Description: GluA1 and GluA2 selective AMPA agonist
Alternative Names: 4-Chlorohomoibotenic acid

Chemical Name: (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid

Purity: ≥99%

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Biological Activity

Cl-HIBO is a subtype-selective and strongly desensitizing AMPA receptor agonist; selective for GluA1 and GluA2 subunit-containing receptors (EC50 values are 4.7, 1.7, 2700 and 1300 μM for rat recombinant homomeric GluA1-4 receptors respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
206.59
Formula:
C6H7ClN2O4
Solubility:
Soluble to 20 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
909400-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
    Bjerrum et al.
    J.Med.Chem., 2003;46:2246
  2. Pharmacological characterization of 4-chlorohomoibotenic acid: a GluR1 and -2 subtype-selective agonist.
    Kristensen et al.
    Soc.Neurosci.Abstr., 2002;:540.7

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