Cystamine dihydrochloride

Key Product Details

Product Description

Cystamine dihydrochloride is a transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

Product Specifications for Cystamine dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cystamine dihydrochloride

The following data is based on the product molecular weight 225.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.20 mL	44.40 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dedeoglu Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 2002 PMID: 12388601
• Mao Cystamine and cyste. prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 2006 PMID: 16623826
• Borrell-Pages Cystamine and cyste. increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 2006 PMID: 16604191

Product Documents for Cystamine dihydrochloride