DMF
Tocris Bioscience | Catalog # 4512
Key Product Details
Description
Alternative Names
Product Description
DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.
Product Specifications for DMF
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.41 | 100 | |
| Ethanol | 7.21 | 50 |
Preparing Stock Solutions for DMF
The following data is based on the product molecular weight 144.13.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.94 mL | 34.69 mL | 69.38 mL |
| 5 mM | 1.39 mL | 6.94 mL | 13.88 mL |
| 10 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 50 mM | 0.14 mL | 0.69 mL | 1.39 mL |
Calculators
Background References
References are publications that support the biological activity of the product.
- Linker Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011 PMID: 21354971
- Scannevin Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 2012 PMID: 22267202
Product Documents for DMF
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for DMF
For research use only
Customer Reviews for DMF (1)
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Species: MouseAssay Type: In VitroCell Line/Tissue: macrophageVerified Customer | Posted 09/24/2019used at 10um in mouse macrophages to activate NRF2
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