MMF
Discontinued Product
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Purity: ≥99%
Biological Activity
MMF is a nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Nature, 2016;0(0):. -
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Rao & Mishra
J.Ethnopharmacol., 1998;60:207 -
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Scannevin et al.
J.Pharmacol.Exp.Ther., 2012;341:274 -
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson et al.
J.Clin.Invest., 2010;120:2910 -
The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist.
Tang et al.
Biochem.Biophys.Res.Commun., 2008;375:562
Product Datasheets
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Citation for MMF
The citations listed below are publications that use Tocris products. Selected citations for MMF include:
1 Citation: Showing 1 - 1
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Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
Authors: Cheng Et al.
Cell Rep. 2020;
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