FR 139317

Key Product Details

Product Description

FR 139317 is a highly potent and selective ET_A endothelin receptor antagonist (K_i values are 1 nM and 7.3 μM at ET_A and ET_B subtypes respectively). Active in vivo.

Product Specifications for FR 139317

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FR 139317

The following data is based on the product molecular weight 604.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.65 mL	8.27 mL	16.54 mL
5 mM	0.33 mL	1.65 mL	3.31 mL
10 mM	0.17 mL	0.83 mL	1.65 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Sogabe Pharmacological profile of FR139317, a novel, potent endothelin ET_A receptor antagonist. J.Pharmacol.Exp.Ther. 1993 PMID: 8450448
• Palacios Role of endothelin ET_A- and ET_B-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats. Br.J.Pharmacol. 2002 PMID: 11861314
• Rubanyi and Polokoff Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol.Rev. 1994 PMID: 7831383
• Aramori Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells. Mol.Pharmacol. 1993 PMID: 8429819

Product Documents for FR 139317