Perindopril erbumine

Key Product Details

Product Description

Perindopril erbumine is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.

Product Specifications for Perindopril erbumine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Perindopril erbumine

The following data is based on the product molecular weight 441.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.53 mL	22.64 mL	45.29 mL
2.5 mM	0.91 mL	4.53 mL	9.06 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ceconi Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 2007 PMID: 17716647
• Dong Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 2011 PMID: 21593435
• Takai Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 2004 PMID: 15080380

Product Documents for Perindopril erbumine