Metalloproteases and Regulators
Metalloproteases are secreted (ADAMTSs, BMP-1, MMPs and Pappalysins), membrane-bound (ACEs, ADAMs, MT-MMPs and Neprilysins), or cytosolic (Insulysin and THOP1). The majority of these proteases are endopeptidases in comparison to the aminopeptidases. MMPs, ADAMs and ADAMTSs are regulated by TIMPs, which have different specificity toward different members of these families.
Aminopeptidases
Angiotensin-Converting Enzymes
| ACE/CD143 | ACE Inhibitors | ACE Substrates | ACE-2 |
Astacins & Astacin-like
| BMP-1/PCP | Meprin alpha Subunit/MEP1A | Meprin beta Subunit/MEP1B | Ovastacin |
Botulinum and Tetanus Neurotoxins (BoNT and TeNT)
| BoNT-A | BoNT-A Light Chain | BoNT-B Light Chain | BoNT-C1 Heavy Chain |
| BoNT-C1 Light Chain | BoNT-D Heavy Chain | BoNT-D Light Chain | BoNT-E Heavy Chain |
| BoNT-E Light Chain | BoNT-F Light Chain | TeNT Light Chain |
Dipeptidases and Aminoacylase
| Aminoacylase/ACY1 | Carnosine Dipeptidase 1/CNDP1 | Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL |
Metalloprotease Regulators
Related Information
- Mini-review: Matrix Metalloproteinases (MMPs)
- Mini-review: ADAMs
- MMP Modulation of Cytokines
- New Tools: Active MMP Activity Assays
- OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression
- New Tools: Proteases & Inhibitors
- ACE-2: The Receptor for SARS-CoV-2
- Need help at the cell surface? Ask your local sheddase.
- Platelet Activation Granule Release
- Table of ADAMs
- Extracellular Matrix and Related Molecules