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DISP1 Products

DISP1 is a multispan (12) transmembrane protein that belongs to a family of sterol-sensing molecules. It is required for paracrine hedgehog signaling by cholesterol-modified SHH. The mechanism by which it does so is unclear; it may facilitate the formation and/or release of SHH oligomers from SHH-producing cells, promoting paracrine SHH diffusion.