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Retinoblastoma 1 (RB1), also known as pRb, is a 928 amino acid (aa) protein with a predicted molecular weight of 106 kDa. It is primarily a nuclear protein, but can also be exported to the cytoplasm. Human RB1 shares 91% and 90% aa sequence identity with the mouse and rat orthologs, respectively. RB1, along with p107 and p130, is a member of the po...