2-MPPA

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
   Majer et al.
   J.Med.Chem., 2003;46:1989
2. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
   Ghadge et al.
   Proc.Natl.Acad.Sci.U.S.A., 2003;100:9554
3. Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism.
   Vornov et al.
   J.Pharmacol.Exp.Ther., 2013;346:406

Product Datasheets