Closed Process Solutions
ProPak™ GMP Cytokines and GMP T Cell Media Bags for T Cell Manufacturing
Designed to Simplify Your Cell Therapy
ProPak GMP cytokines and bagged GMP T cell media were created to help reduce variability and risk in your T cell therapy. GMP IL-2, IL-7, IL-15, and Human T Cell Media are now available in single-use bags, designed to integrate seamlessly into your closed process workflow. IL-2 is available by mass or IU.
View all available ready-to-use protein formats and see how optimal cytokine dosing was determined with data from a cytokine titration study.
G-Rex® cell manufacturing platform is available through our partnership with ScaleReady™.
Available Closed Process GMP Reagents | ||||
| IL-2 | IL-7 | IL-15 | T Cell Media | Human AB Serum |
Closed System Process
ProPak GMP cytokines and GMP T cell media bags are designed to integrate seamlessly into a closed system process, mitigating the risk of contamination.
Weldable Tubing
Easily integrate ProPaks into your workflow. Industry standard PVC tubing creates a fully closed cytokine addition step that can then be added to a 1 L bioreactor, such as the G-Rex.
Optimized Performance
Our studies have identified optimal doses of IL-2, IL-7, and IL-15 in a 1 L T or NK cell culture process. We also offer made-to-order ProPak options filled to your specifications, ensuring ProPaks supply the ideal amount of protein for your process.
Reduced Manual Touchpoints
Eliminating reconstitution and aliquoting steps reduces hands-on technician time under a BSC hood. This reduces risks of error while streamlining your journey to the clinic.
Ready-to-Use Format
ProPak GMP cytokines can be stored at -20 °C for long term storage or at 2-8 °C for up to 2 weeks. Accelerated stability testing currently underway to support a 2 year shelf-life at -20 °C.
GMP Human T Cell Media can be stored at 2-8 °C and protected from light, up to the use by date on the Certificate of Analysis.
Customize ProPaks to Fit Your Workflow
Made-to-Order Options:
Fill to your desired protein quantity of IL-2, IL-7, or IL-15
• 10 µg to 1.5 mg
• 150k to 15M IU (IL-2)
• No additional charges for MTO fill or validation
Custom fill with other E. coli-derived GMP cytokines
• Custom validation fees may apply
Have questions, want to order a custom ProPak, or need a protein not on the following list? Contact us with the form below.
Closed System App Note
Compare ProPak cytokines in a closed system with conventional lyophilized cytokines in CAR-T cell manufacturing workflows.
ProPak User Manual
Learn how to add ProPak GMP cytokines into your closed process for seamless ex vivo clinical production.
Weldable Workflow Poster
Learn how closed process reagents can help streamline the transition to scalable closed system cell therapy manufacturing.
ProPak, liquid, or lyophilized IL-7 and IL-15 were added to Xeno-free GMP Human T Cell Media (Catalog # CCM038-GMP) with 5% huAB Serum. T cells from 3 donors were activated and expanded in G-Rex bioreactors for 9 days and assessed for fold expansion and cell viability. Data is the average of 4 independent experiments with 3 donors per experiment, error bars ± SD.