Primary antibodies, secondary antibodies and isotype controls

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Primary Antibodies, Secondary Antibodies, and Isotype Controls From R&D Systems

An antibody is a Y shaped protein that is produced in the immune system and is designed to target a specific protein or molecule. Due to the highly specific nature of antibodies, they can be used as powerful tools for research. Over the years a variety of techniques and applications have been developed using antibodies. These include Immunoassays, Flow Cytometry, Immunohistochemistry, Western blotting and more.

R&D Systems offers a wide range of antibodies to cytokines, adhesion molecules, proteases, neurotrophic factors, stem cell factors, signal transduction molecules, and developmental proteins. Monoclonal and polyclonal antibodies are available with multiple labeled options or unlabeled. With over 20,000 antibody products validated in 25+ species and 15+ applications, our antibodies fit into all work flows.

Product Categories

Antibody Quality and Reproducibility

The R&D Systems Approach to Quality
Our commitment to quality is unmatched. Learn about how we generate our high-quality antibodies.

Built for Reproducibility
Results are everything, trust our antibodies. Learn about our commitment to antibody reproducibility.

Antibody Matchmaker
We make switching antibody suppliers easy.

Primary Antibodies

Bulk Antibodies
We have the ability to scale up antibody production to meet your needs. Economical pricing means you don't have to sacrifice quality to meet your budget.

Recombinant Monoclonal Antibodies
Minimize one source of experimental variability with our selection of recombinant antibodies. We offer recombinant rabbit monoclonal antibodies as well as recombinant mouse and rat antibodies from our traditional hybridomas.

Custom Antibody Development
Utilize our expertise in cloning antigens and antibody engineering processes to create the antibody of your choice.

Biosimilar Antibodies
Our Biosimilar Antibodies are recombinantly expressed using the same sequence as the Therapeutic antibody. They are a great option for research use.

Anti-Idiotype Antibodies
Take advantage of our highly specific Anti-Idiotype antibodies to target biosimilar antibodies.

Conjugated Antibodies
Choose from a variety of conjugations options to customize your research.

Sample Size Antibodies
Test our antibodies with a smaller amount before purchasing a larger quantity.

Primary Antibodies by Application

Flow Cytometry Antibodies
Conjugated antibodies for surface and intracellular staining. Available in 100 tests and or 25 test sizes 100 µg, 100 tests, and 25 test sizes.

Immunohistochemistry and Immunocytochemistry Antibodies
Highly specific antibodies for IHC and ICC.

Blocking/Neutralizing Antibodies
Our extensive collection of proteins and our bioassay expertise allow us to provide the best and most dependable selection of blocking/neutralizing antibodies on the market.

Western Blot Antibodies
View the full list of validated antibodies for Western blot.

Simple Western™ Certified Antibodies
The largest collection of Simple Western certified antibodies. All antibodies certified in-house by our experienced scientists for use on your Wes, Sally Sue, and Peggy Sue.

Matched Antibody Pairs for ELISA
Qualified capture and detection antibody pairs for assay development on various assay platforms.

CyTOF Ready Antibodies
Take advantage of our large selection of antibodies that are ready to be used in CyTOF.

Knockout Validated Antibodies
Specificity that has been confirmed with knockout cell lysates.


Secondary Reagents & Isotype Controls

Secondary Antibodies and Antibody Controls
Find the right secondary antibody and antibody control for your primary antibody.

NorthernLights™ Fluorescent Secondary Antibodies
NorthernLight conjugated secondary antibodies are bright and resistant to photobleaching.

VisUCyte™ HRP Polymer
Get cleaner and faster IHC results.

Antibody Protocols, Principles, and Guides

Flow Cytometry Protocols
Protocols designed for staining membrane-associated proteins and intracellular molecules.

Flow Cytometry eHandbook
An overview of Flow Cytometry techniques with step-by-step instructions.

Immunohistochemistry (IHC) Protocols
Learn to stain paraffin-embedded and frozen tissue with our IHC protocols.

Immunocytochemistry (ICC) Protocols
Visualize your cells with our ICC protocols.

IHC/ICC Optimization Protocols
Learn to optimize your IHC and ICC results with specific staining and epitope retrieval.

IHC/ICC Protocol Guide
A full IHC and ICC staining guide to get your best results.

Western Blot Protocols
Use our in-house Western blot protocols to identify your next protein.