Catalog Number: 2281
Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
Biological Activity
Potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
    Franchetti et al.
    J.Med.Chem., 1998;41:1708
  2. Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
    Cappellacci et al.
    J.Med.Chem., 2005;48:1550
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