Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
Biological Activity2'-MeCCPA is a potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Franchetti et al.
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Cappellacci et al.
Citations for 2'-MeCCPA
The citations listed below are publications that use Tocris products. Selected citations for 2'-MeCCPA include:
2 Citations: Showing 1 - 2
Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
Authors: Liu Et al.
Brain Res 2018;1700:47
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
Authors: Yang Et al.
Eur J Immunol 2010;40:449
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