Potent and highly selective agonist at A1
adenosine receptors (Ki
values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1
receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50
value of 13.1 nM.
Soluble to 25 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Franchetti et al.
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
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