Irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
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Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons.
de Oca Balderas et al.
3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway.
Solesio et al.
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
Huang et al.