Basement membrane extract (BME) is a type of extracellular matrix (ECM) derived from Engelbreth-Holm-Swarm mouse sarcomas. BME is commonly used in cell culture and tissue engineering to provide a 2-D or 3-D scaffold for cells, allowing them to grow, differentiate, and interact in an environment that closely mimics the native ECM. This makes BME invaluable for modeling the behavior of cells in vivo. All Cultrex BME formulations are rigorously tested to ensure performance, quality, and lot-to-lot consistency.
Cultrex Basement Membrane Extract, 5X Solution
R&D Systems | Catalog # 3455-096-02
Discontinued Product
3455-096-02 has been discontinued.
View all Basement Membrane Extracts products.
Key Product Details
Features
Cultrex 5X Basement Membrane Extract (BME) Solution is designed for use in Cultrex BME Cell Invasion Assays.
Species
Multi-Species
Product Summary for Cultrex Basement Membrane Extract, 5X Solution
Why Use Cultrex BME, 5X Solution?
Cultrex Basement Membrane Extract (BME) is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. This extract provides a natural extracellular matrix hydrogel that polymerizes at 37°C to form a reconstituted basement membrane. Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans.
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Product Specifications
Source
Murine Engelbreth-Holm-Swarm (EHS) tumor
Endotoxin Level
≤ 8 EU/mL by Limulus Amoebocyte Lysate (LAL) assay
Sterility Testing
Tested following USP 71> sterility guidelines.
Cell Culture Testing
Performance tested in Cultrex BME Cell Invasion Assay.
Formulation, Preparation, and Storage
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Basement Membrane Extracts
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Product Documents for Cultrex Basement Membrane Extract, 5X Solution
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Citations for Cultrex Basement Membrane Extract, 5X Solution
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