Biological Activity9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.
Simard et al.
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
Grand et al.
Citations for 9-Phenanthrol
The citations listed below are publications that use Tocris products. Selected citations for 9-Phenanthrol include:
2 Citations: Showing 1 - 2
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.
Authors: O'Malley Et al.
J Neurosci 2020;40:4813
Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex.
Authors: Lin Et al.
Front Cell Neurosci 2017;11:182
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