Biological ActivitySelective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.
Simard et al.
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
Grand et al.
Citation for 9-Phenanthrol
The citations listed below are publications that use Tocris products. Selected citations for 9-Phenanthrol include:
1 Citation: Showing 1 - 1
Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex.
Authors: Lin Et al.
Front Cell Neurosci 2017;11:182
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