Catalog Number: 4999
Chemical Name: 9-Hydroxyphenanthrene
Biological Activity
Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
Technical Data
  • M.Wt:
    194.23
  • Formula:
    C14H10O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    484-17-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.
    Simard et al.
    Br.J.Pharmacol., 2012;165:2354
  2. 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
    Grand et al.
    Br.J.Pharmacol., 2008;153:1697

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