9-Phenanthrol

Key Product Details

Product Description

9-Phenanthrol is a selective TRPM4 blocker (IC₅₀ = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.

Product Specifications for 9-Phenanthrol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 9-Phenanthrol

The following data is based on the product molecular weight 194.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.15 mL	25.74 mL	51.49 mL
5 mM	1.03 mL	5.15 mL	10.30 mL
10 mM	0.51 mL	2.57 mL	5.15 mL
50 mM	0.10 mL	0.51 mL	1.03 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Grand 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 2008 PMID: 18297105
• Simard Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 2012 PMID: 22014185

Product Documents for 9-Phenanthrol