Selective TRPM4 blocker (IC50
= 20 μ
M in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
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Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.
Simard et al.
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
Grand et al.