Biological ActivitySelective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle.
Simard et al.
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
Grand et al.
Citations for 9-Phenanthrol
The citations listed below are publications that use Tocris products. Selected citations for 9-Phenanthrol include:
2 Citations: Showing 1 - 2
TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.
Authors: O'Malley Et al.
J Neurosci 2020;40:4813
Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex.
Authors: Lin Et al.
Front Cell Neurosci 2017;11:182
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