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9-Phenanthrol

Catalog #: 4999
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4999/50

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9-Phenanthrol | CAS No. 484-17-3 | TRPM Agonists
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Description: Selective TRPM4 blocker

Chemical Name: 9-Hydroxyphenanthrene

Product Details
Citations (4)
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Biological Activity

9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.

Technical Data

M.Wt:
194.23
Formula:
C14H10O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at +4°C
CAS No:
484-17-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 9-Phenanthrol

The citations listed below are publications that use Tocris products. Selected citations for 9-Phenanthrol include:

4 Citations: Showing 1 - 4

  1. TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing.
    Authors: Douglas A Et al.
    Cell Rep  2021;34:108714
  2. Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
    Authors: Virginie Et al.
    Nat Commun  2021;12:6815
  3. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.
    Authors: O'Malley Et al.
    J Neurosci  2020;40:4813
  4. Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex.
    Authors: Lin Et al.
    Front Cell Neurosci  2017;11:182

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