(±)-α-Lipoamide

Key Product Details

Product Description

(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC₅₀ = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Product Specifications for (±)-α-Lipoamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-α-Lipoamide

The following data is based on the product molecular weight 205.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.87 mL	24.35 mL	48.70 mL
5 mM	0.97 mL	4.87 mL	9.74 mL
10 mM	0.49 mL	2.44 mL	4.87 mL
50 mM	0.10 mL	0.49 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shen Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 2011 PMID: 21108628

Product Documents for (±)-α-Lipoamide