(±)-α-Lipoamide

Catalog # Availability Size / Price Qty
7045/100
(±)-α-Lipoamide | CAS No. 940-69-2 | Buffers, Chelators and Reagents
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Description: Phase-separated condensate modifier; orally bioavailable

Chemical Name: 1,2-Dithiolane-3-pentanamide

Purity: ≥98%

Product Details
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Biological Activity

Phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Technical Data

M.Wt:
205.33
Formula:
C8H15NOS2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
940-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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