(±)-α-Lipoamide
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Description: Phase-separated condensate modifier; orally bioavailable
Chemical Name: 1,2-Dithiolane-3-pentanamide
Purity: ≥98%
Biological Activity
(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC50 = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.Technical Data
M.Wt:
205.33
Formula:
C8H15NOS2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
940-69-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway.
Shen et al.
Br.J.Pharmacol., 2011;162:1213
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