Catalog Number: 2484
Chemical Name: (±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
Biological Activity
Highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in water and to 75 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954).
    Croston et al.
    J.Med.Chem., 2002;45:4950
  2. Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists.
    Lavecchia et al.
    J.Med.Chem., 2005;48:2480
  3. Novel potent and efficacious nonpeptidic urotensin II receptor agonists.
    Lehmann et al.
    J.Med.Chem., 2006;49:2232
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