Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Biological Activity Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Desiccate at +4°C
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