Catalog Number: 0497
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
    J.Med.Chem., 1996;39:4905
  2. Tyrphostins as molecular tools and potential antiproliferative drugs.
    Levitzki and Gilon
    TiPS, 1991;12:171
  3. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
    Yamamoto et al.
    J.Cell Sci., 2006;119:4623
  4. Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors.
    Gazit et al.
    J.Med.Chem., 1989;32:2344
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