Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50
= 10 μ
M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met
and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro
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Tyrphostins as molecular tools and potential antiproliferative drugs.
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J.Cell Sci., 2006;119:4623
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