Catalog Number: 0497
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
Technical Data
  • M.Wt:
    204.18
  • Formula:
    C10H8N2O3
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    122520-85-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.
    Gazit
    J.Med.Chem., 1996;39:4905
  2. Tyrphostins as molecular tools and potential antiproliferative drugs.
    Levitzki and Gilon
    TiPS, 1991;12:171
  3. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
    Yamamoto et al.
    J.Cell Sci., 2006;119:4623
  4. Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors.
    Gazit et al.
    J.Med.Chem., 1989;32:2344

Have you used AG 99?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information