Sesquiterpene lactone. Induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction. Displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells.
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Toxic effect of alantolactone and dihydroalantolactone in in vitro cultures of leukocytes.
Dupuis & Brisson et al.
Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway.
Shi et al.
Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cellsby Inula racemosa.
Pal et al.
Toxicol.In Vitro., 2010;24:1599