AMI-193

Tocris Bioscience | Catalog # 0524

D2-like antagonist; also selective 5-HT2 antagonist
Tocris Bioscience
Discontinued Product
0524 has been discontinued. View all Non-selective Dopamine Receptor Antagonists products.

Key Product Details

Description

D2-like antagonist; also selective 5-HT2 antagonist

Alternative Names

Spiramide
View all Non-selective Dopamine Receptor Antagonists »

Product Description

AMI-193 is a selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Product Specifications for AMI-193

Molecular Weight

383.46

Formula

C22H26FN3O2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone

CAS Number

510-74-7

PubChem ID

68186

InChI Key

FJUKDAZEABGEIH-UHFFFAOYSA-N

SMILES

FC(C=C4)=CC=C4OCCCN1CCC2(N(C3=CC=CC=C3)CNC2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.76 75

Preparing Stock Solutions for AMI-193

The following data is based on the product molecular weight 383.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.48 mL 17.39 mL 34.77 mL
3.75 mM 0.70 mL 3.48 mL 6.95 mL
7.5 mM 0.35 mL 1.74 mL 3.48 mL
37.5 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AMI-193

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMI-193

For research use only

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