Catalog Number: 2132
Alternate Names: DAN 2163
Chemical Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
Biological Activity
Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
Technical Data
  • M.Wt:
    369.48
  • Formula:
    C17H27N3O4S
  • Solubility:
    Soluble to 25 mM in 1eq. HCl with gentle warming and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    71675-85-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity.
    Perrault et al.
    J.Pharmacol.Exp.Ther., 1997;280:73
  2. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.
    Schoemaker et al.
    J.Pharmacol.Exp.Ther., 1997;280:83
  3. Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.
    Moller
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2003;27:1101
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amisulpride include:

2 Citations: Showing 1 - 2
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  1. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol 2012;167:1480
  2. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One 2011;6:e25395

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