Amisulpride

Catalog # Availability Size / Price Qty
2132/50
Amisulpride | CAS No. 71675-85-9 | Non-selective Dopamine Receptor Antagonists
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Description: Selective D2 and D3 antagonist; atypical antipsychotic
Alternative Names: DAN 2163

Chemical Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

Technical Data

M.Wt:
369.48
Formula:
C17H27N3O4S
Solubility:
Soluble to 25 mM in 1eq. HCl with gentle warming and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
71675-85-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 DA receptor antagonist activity and limbic selectivity.
    Perrault et al.
    J.Pharmacol.Exp.Ther., 1997;280:73
  2. Neurochemical characteristics of amisulpride, an atypical DA D2/D3 receptor antagonist with both presynaptic and limbic selectivity.
    Schoemaker et al.
    J.Pharmacol.Exp.Ther., 1997;280:83
  3. Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.
    Moller
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2003;27:1101

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Citations for Amisulpride

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