Amisulpride

  ( 2 citations )    
Product Datasheet
Catalog Number:2132
Alternate Names:DAN 2163
Chemical Name:4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
Product Details
Citations (2)
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Biological Activity
Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
Technical Data
  • M.Wt:
    369.48
  • Formula:
    C17H27N3O4S
  • Solubility:
    Soluble to 25 mM in 1eq. HCl with gentle warming and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    71675-85-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amisulpride include:

2 Citations: Showing 1 - 2
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  1. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol  2012;167:1480
  2. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One  2011;6:e25395

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