Potent, selective dopamine D2
receptor antagonist. Ki
values are 2.8 and 3.2 nM respectively for human D2
and > 1000 nM for human D1
receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2
receptors at higher doses. Preferentially interacts with limbic D2
-like receptors in vivo
. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
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Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity.
Perrault et al.
Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.
Schoemaker et al.
Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.
The citations listed below are publications that use Tocris products. Selected citations for Amisulpride include:
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