Catalog Number: 4177
Chemical Name: 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
Biological Activity
GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion.
    Yoshida et al.
    Biochem.Biophys.Res.Commun., 2010;400:437
  2. Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag.
    Chepurny et al.
    Mol.Endocrinol., 2013;27:1267
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