AV 412

Catalog # Availability Size / Price Qty
4397/10
EGF Receptor Inhibitors Small Molecule
1 Image
Description: Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide

Purity: ≥98%

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Biological Activity

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.

Technical Data

M.Wt:
507
Formula:
C27H28ClFN6O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
451492-95-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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