Catalog Number: 5375
Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid
Biological Activity
BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.
    Inokuchi et al.
    Invest.Ophthalmol.Vis.Sci., 2009;50:334
  2. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil.
    Oida et al.
    Brain Res., 2008;1208:217
  3. A molecular chaperone inducer protects neurons from ER stress.
    Kudo et al.
    Cell Death Differ., 2008;15:364

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