BIX

Key Product Details

Product Description

BIX is a BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.

Product Specifications for BIX

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BIX

The following data is based on the product molecular weight 209.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.78 mL	23.90 mL	47.80 mL
5 mM	0.96 mL	4.78 mL	9.56 mL
10 mM	0.48 mL	2.39 mL	4.78 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Oida Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 2008 PMID: 18395193
• Kudo A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008 PMID: 18049481
• Inokuchi Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 2009 PMID: 18757512

Product Documents for BIX