Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid
Biological ActivityBIX is a BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
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Complete Your Research
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.
Inokuchi et al.
Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil.
Oida et al.
Brain Res., 2008;1208:217
A molecular chaperone inducer protects neurons from ER stress.
Kudo et al.
Cell Death Differ., 2008;15:364
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