CALP3
Biological Activity
CALP3 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
Manion et al.
FASEB J., 2000;14:1297 -
Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.
Ten Broeke et al.
Eur.J.Pharmacol., 2003;476:151 -
De novo design of peptides targeted to the EF hands of calmodulin.
Villain et al.
J.Biol.Chem., 2000;274:2676
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for CALP3
The citations listed below are publications that use Tocris products. Selected citations for CALP3 include:
1 Citation: Showing 1 - 1
-
BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
Authors: Ferdek Et al.
Cell.Death.Dis. 2017;8:e2640
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for CALP3
There are currently no reviews for this product. Be the first to review CALP3 and earn rewards!
Have you used CALP3?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
