CALP3
Biological Activity
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
Manion et al.
FASEB J., 2000;14:1297 -
Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.
Ten Broeke et al.
Eur.J.Pharmacol., 2003;476:151 -
De novo design of peptides targeted to the EF hands of calmodulin.
Villain et al.
J.Biol.Chem., 2000;274:2676
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Citation for CALP3
The citations listed below are publications that use Tocris products. Selected citations for CALP3 include:
1 Citation: Showing 1 - 1
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BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
Authors: Ferdek Et al.
Cell.Death.Dis. 2017;8:e2640
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