Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+
-binding site. Activates phosphodiesterase in the absence of Ca2+
and inhibits Ca2+
-mediated cytotoxicity and apoptosis (IC50
= 33 μ
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A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
Manion et al.
FASEB J., 2000;14:1297
Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma.
Ten Broeke et al.
De novo design of peptides targeted to the EF hands of calmodulin.
Villain et al.