Catalog Number: 2193
Alternate Names: EMD 45609
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole-5-carboxylic acid hydrochloride
Biological Activity
Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Technical Data
  • M.Wt:
    410.94
  • Formula:
    C24H26N2O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    115092-85-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological basis for antihypertensive therapy with a novel dopamine agonist
    Haeusler et al.
    Eur.Heart J., 1992;13:129
  2. Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices.
    Rump et al.
    Eur.J.Clin.Pharmacol., 1993;44:S47
  3. Neurochemical profile of EMD 45609 (carmoxirole), a dopamine DA2-receptor agonist.
    Hasse et al.
    Naunyn-Schmied.Arch.Pharmacol., 1991;343:588
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Carmoxirole hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression.
    Authors: Schlenker Et al.
    Respir Physiol Neurobiol 2014;193:29
  2. Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain.
    Authors: Schlenker and Schultz
    Respir Physiol Neurobiol 2012;180:69

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