CDP 840 hydrochloride

Key Product Details

Product Description

CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC₅₀ = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC₅₀ values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast).

Product Specifications for CDP 840 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CDP 840 hydrochloride

The following data is based on the product molecular weight 409.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.20 mL	24.39 mL
5 mM	0.49 mL	2.44 mL	4.88 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Perry CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 1998 PMID: 9631241
• Cooper A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 1999 PMID: 10372831
• Hughes The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 1996 PMID: 8818342

Product Documents for CDP 840 hydrochloride