Ceranib 1

Tocris Bioscience | Catalog # 4448

Ceramidase inhibitor; antiproliferative
Tocris Bioscience
Discontinued Product
4448 has been discontinued. View all Ceramidase Inhibitors products.

Key Product Details

Description

Ceramidase inhibitor; antiproliferative
View all Ceramidase Inhibitors »

Product Description

Ceranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Product Specifications for Ceranib 1

Molecular Weight

395.45

Formula

C26H21NO3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone

CAS Number

328076-61-5

PubChem ID

5761166

InChI Key

OJMCCNQNCSCAJV-RVDMUPIBSA-N

SMILES

O=C2C(C(/C=C/C4=CC=C(OC)C=C4)=O)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.55 100

Preparing Stock Solutions for Ceranib 1

The following data is based on the product molecular weight 395.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Ceranib 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ceranib 1

For research use only

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