Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Biological ActivityCeranib 1 is a ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery and evaluation of inhibitors of human ceramidase.
Draper et al.
Mol. Cancer Ther., 2011;10:2052
Citation for Ceranib 1
The citations listed below are publications that use Tocris products. Selected citations for Ceranib 1 include:
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