Catalog Number: 4448
Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone
Biological Activity
Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.
Technical Data
  • M.Wt:
    395.45
  • Formula:
    C26H21NO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    328076-61-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and evaluation of inhibitors of human ceramidase.
    Draper et al.
    Mol. Cancer Ther., 2011;10:2052
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ceranib 1 include:

1 Citations: Showing 1 - 1

  1. The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
    Authors: Davis
    Sci Rep 2015;12:847

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