Ceranib 1

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Ceranib 1 | CAS No. 328076-61-5 | Ceramidase Inhibitors
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Description: Ceramidase inhibitor; antiproliferative

Chemical Name: 3-[(2E)-3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-6-methyl-4-phenyl-2(1H)-quinolinone

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Ceramidase inhibitor; inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM). Induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells.

Technical Data

M.Wt:
395.45
Formula:
C26H21NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
328076-61-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery and evaluation of inhibitors of human ceramidase.
    Draper et al.
    Mol. Cancer Ther., 2011;10:2052

Product Datasheets

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Citation for Ceranib 1

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