CGH 2466 dihydrochloride

Catalog # Availability Size / Price Qty
CGH 2466 dihydrochloride | CAS No. 1177618-54-0 | Non-selective Adenosine Receptor Antagonists
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Description: A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4

Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products

Biological Activity

CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

Technical Data

Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for CGH 2466 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CGH 2466 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. An Adenosine Receptor for Olfaction in Fish.
    Authors: Wakisaka Et al.
    Curr Biol  2017;27:1437


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