CGH 2466 dihydrochloride

Key Product Details

Product Description

CGH 2466 dihydrochloride is an adenosine A₁, A_2B and A₃ receptor antagonist (IC₅₀ values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC₅₀ = 187 - 400 nM) and phosphodiesterase type 4D (IC₅₀ = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.

Product Specifications for CGH 2466 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGH 2466 dihydrochloride

The following data is based on the product molecular weight 395.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.31 mL	126.54 mL	253.08 mL
0.5 mM	5.06 mL	25.31 mL	50.62 mL
1 mM	2.53 mL	12.65 mL	25.31 mL
5 mM	0.51 mL	2.53 mL	5.06 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

• Trifilieff CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br.J.Pharmacol. 2005 PMID: 15685201

Product Documents for CGH 2466 dihydrochloride