Catalog Number: 2344
Chemical Name: 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride
Biological Activity
Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Displays potent anti-inflammatory effects in vitro and in vivo. Potentially useful for asthma and chronic obstructive pulmonary disease (COPD) research.
Technical Data
  • M.Wt:
    395.13
  • Formula:
    C14H9N3SCl2.2HCl
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1177618-54-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities.
    Trifilieff et al.
    Br.J.Pharmacol., 2005;144:1002

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