Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Biological ActivityCinnabarinic acid is a mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
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Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors.
Mol.Pharmacol., 2012;Feb 6:Epub ahead of print
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