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Cinnabarinic acid

4119 Datasheet / COA / SDS

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Cinnabarinic acid | CAS No. 606-59-7 | Group III mGluR Agonists
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Description: Selective mGlu4 agonist

Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid

Purity: ≥98%

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Biological Activity

Cinnabarinic acid is a mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.

Technical Data

M.Wt:
300.22
Formula:
C14H8N2O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
606-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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