Catalog Number: 4119
Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Biological Activity
mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors.
    Mol.Pharmacol., 2012;Feb 6:Epub ahead of print
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