receptor agonist. Activates mGlu4
receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1
). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
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All Tocris products are intended for laboratory research use only.
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors.
Mol.Pharmacol., 2012;Feb 6:Epub ahead of print