Catalog Number: 0457
Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Biological Activity
Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.
Technical Data
  • M.Wt:
    351.32
  • Formula:
    C19H23ClN2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    17321-77-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
    Owens et al.
    J.Pharmacol.Exp.Ther., 1997;283:1305
  3. Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder.
    McTavish and Benfield
    Drugs, 1990;39:136
  4. Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluoxetine.
    Ortiz and Artiga
    Br.J.Pharmacol., 1992;105:941
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clomipramine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    Eur J Neurosci 2015;352:53
  2. The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Biomed Sci 2010;31:1646

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