Biological ActivityGluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC 50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC 50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro. Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
(Modifications: X = Gla, Asn-17 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors.
Donevan and McCabe
Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, a naturally occurring conopeptide.
Bush et al.
Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies.
Williams et al.
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VersaClone cDNA Plasmids
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