Catalog Number: 4136
Biological Activity
NR2B-selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing N2RB, but not NR2A, subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.
Technical Data
  • M.Wt:
    2264.21
  • Formula:
    C88H138N26O44
  • Sequence:
    GEXXLQXNQXLIRXKSN

    (Modifications: X = Gla, Asn-17 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    93438-65-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, a naturally occurring conopeptide.
    Bush et al.
    Eur.J.Pharmacol., 2000;387:55
  2. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors.
    Donevan and McCabe
    Mol.Pharmacol., 2000;58:614
  3. Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies.
    Williams et al.
    J.Pharmacol.Exp.Ther., 2000;294:378

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