Conantokin G

Name: Conantokin G
Brand: Tocris Bioscience
SKU: 4136

Tocris Bioscience | Catalog # 4136

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GluN2B-selective NMDA antagonist

Discontinued Product

4136 has been discontinued. View all NMDA Receptor Antagonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

GluN2B-selective NMDA antagonist

View all NMDA Receptor Antagonists »

Product Description

Conantokin G is a GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC₅₀ = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC₅₀ ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for Conantokin G

Molecular Weight

2264.21

Formula

C₈₈H₁₃₈N₂₆O₄₄

Storage

Store at -20°C

CAS Number

93438-65-4

PubChem ID

16132376

InChI Key

HTBKFGWATIYCSF-UHFFFAOYSA-N

SMILES

CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CC(C(O)=O)C(O)=O)NC(=O)C(CCC(O)=O)NC(=O)CN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C(O)=O)C(O)=O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Bush Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 2000 PMID: 10633160
Williams Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 2000 PMID: 10871336
Donevan and McCabe Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 2000 PMID: 10953056

Product Documents for Conantokin G

Certificate of Analysis

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Product Specific Notices for Conantokin G

For research use only

Related Research Areas

The Glutamatergic System in Alzheimer's Disease

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