(-)-Cotinine
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Purity: ≥99%
Biological Activity
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.
Buccafusco and Terry
Life Sci., 2003;72:2931 -
Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition.
Terry et al.
CNS Drug Rev., 2005;11:229 -
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.
Echeverria et al.
J.Alzheimers Dis., 2011;23:1
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