Catalog Number: 3110
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Biological Activity
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.
    Buccafusco and Terry
    Life Sci., 2003;72:2931
  2. Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition.
    Terry et al.
    CNS Drug Rev., 2005;11:229
  3. Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum.
    O'Leary et al.
    , 2008;325:646
  4. Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.
    Echeverria et al.
    J.Alzheimers Dis., 2011;23:1
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