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(-)-Cotinine

3110 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3110/50
(-)-Cotinine | CAS No. 486-56-6 | Additional Nicotinic Receptor Agonists
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Description: Major metabolite of nicotine

Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone

Purity: ≥99%

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Biological Activity

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Technical Data

M.Wt:
176.22
Formula:
C10H12N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
486-56-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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