Major metabolite of nicotine. Shown to activate a subpopulation of α
2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo
; reduces amyloid β
) aggregation and improves memory in an Alzheimer's disease mouse model.
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The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.
Buccafusco and Terry
Life Sci., 2003;72:2931
Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition.
Terry et al.
CNS Drug Rev., 2005;11:229
Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum.
O'Leary et al.
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.
Echeverria et al.
J.Alzheimers Dis., 2011;23:1