(-)-Cotinine
Discontinued Product
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Purity: ≥99%
Biological Activity
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The potential role of cotinine in the cognitive and neuroprotective actions of nicotine.
Buccafusco and Terry
Life Sci., 2003;72:2931 -
Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition.
Terry et al.
CNS Drug Rev., 2005;11:229 -
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice.
Echeverria et al.
J.Alzheimers Dis., 2011;23:1
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for (-)-Cotinine
There are currently no reviews for this product. Be the first to review (-)-Cotinine and earn rewards!
Have you used (-)-Cotinine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
