Catalog Number: 3783
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine
Biological Activity
Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex.
    Hertel et al.
    Neuropharmacology, 1999;38:1175
  2. CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon.
    Mansbach et al.
    Psychopharmacology, 1996;128:313
  3. Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo.
    Rollema et al.
    J.Neurochem., 1996;67:2204
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