CP 135807
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine
Purity: ≥98%
Biological Activity
Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon.
Mansbach et al.
Psychopharmacology, 1996;128:313 -
Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo.
Rollema et al.
J.Neurochem., 1996;67:2204 -
The antipsychotic drug risper. interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex.
Hertel et al.
Neuropharmacology, 1999;38:1175
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